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This is a hereditary disorder that affects the lysosomes due to an enzyme deficiency.   This creates a loss of myelin, the insulator of the neurons and an excess of lipids that should form the myelin sheath.  This prevents the nerves from being able to properly transmit their impulses.  There can even be a disruption of the axon of the nerve that will block any transmission of that neuron.  Early symptoms can mimic cerebral palsy but the disease will progress until death.  Some breeds are more prone to this disease; Australian Kelpie, Bluetick Coonhound, Carin Terrier, Irish Setter, Miniature Poodle, and West Highland Terrier.  Symptoms can include:

  • Weakness
  • Loss of Appetite
  • Loss of Muscle Mass
  • Lack of Coordination
  • Behavioral Changes
  • Anorexia
  • Dementia
  • Incontinence
  • Tremors
  • Blindness
  • Deafness
  • Difficulty Swallowing
  • Paralysis
  • Seizure
  • Death